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KMID : 0364519930050010047
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Dong-A Journal Medicine
1993 Volume.5 No. 1 p.47 ~ p.54
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Comparison of Cardioprotective Effect of Modified GIK cardioplegic solution with St. Thomas' Hospital cardioplegic solution
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Abstract
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The protective effect of modified GIK(glucose-insulin-potassium) cardioplegic solution which contains sodium (86.1mmol/L) and low calcium (0.6mmol/L) was compared with St. Thomas' Hospital cardioplegic solution in pediatric cardiac patients who
underwent patchy repairs of VSD. Requirement of electric defibrillation. Development of postoperative arrhythmia, and postoperative catecholamine requirement were evaluated in 43 patients. 25 patients received. St. Thomas' hospital solution (ST
group)
and 18 received modified GIK solution (mGIK group). The serum creatine kinase MB activity at 6 hours of reperfusion and left ventricular shortening fraction 10 days to 14 days after operation were evaluated in 20 patients; 10 patients received
St.
Thomas' Hospital solution and 10 received modified GIK solution. There was no significant difference between the two groups in age, body weight, and aortic cross-clamping time. On reperfusion. Electrical defibrillation was required in 8 patients
of
ST
group and not required in all patient of mGIK group (32% versus 0%). The postoperative bradyarrhythmia was noted in 6 patients of ST group and no arrhythmia in mGIK group (24% versus 0%) . 7 patients in ST group required more than 10μg/kg/min of
dopamine in the postoperative period. But only one in mGIK group did (28% versus 5.6%). The serum creatine kinase MB activity was significantly lower in mGIK group (236.±10.1 versus 36.4±11.2IU/L p<0.05) and the recovery of left ventricular
shortening
fraction in mGIK group is better than in ST group (115±27.5% versus 93.7±23.6% p<0.05). It is concluded that lower sodium, lower calcium, and magnesium free modified GI solation has superior protective effect to St. Thomas' Hospital solution.
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KEYWORD
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